Targeting WASP

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.

Cell morphology and motility are governed largely by complex signaling networks that ultimately engage the actin cytoskeleton. Understanding how individual circuits contribute to the process of forming cellular structures would be aided greatly by the availability of specific chemical inhibitors. We have used a novel chemical screen in Xenopus cell-free extracts to identify compounds that inhib...

A Wasp Sting.

SPITZER SECONDARY ECLIPSE DEPTHS WITH MULTIPLE INTRAPIXEL SENSITIVITY CORRECTION METHODS OBSERVATIONS OF WASP-13b, WASP-15b, WASP-16b, WASP-62b, AND HAT-P-22b

We measure the 4.5 μm thermal emission of five transiting hot Jupiters, WASP-13b, WASP-15b, WASP-16b, WASP-62b, and HAT-P-22b using channel 2 of the Infrared Array Camera (IRAC) on the Spitzer Space Telescope. Significant intrapixel sensitivity variations in Spitzer IRAC data require careful correction in order to achieve precision on the order of several hundred parts per million (ppm) for the...

Wasp Polydnavirus Polymorphism

In this paper, we analyze the polymorphisms of parasitoid wasp polydnavirus. The polydnavius genome is normally dormant within the genome of the wasp, but is converted into particles that are injected into the infected host along with the wasp eggs. These particles contain genes which inhibit the immune system of the infected host, and are necessary for the eggs to mature. Within a population, ...

From Dense Hot Jupiter to Low Density Neptune: The Discovery of WASP-127b, WASP-136b and WASP-138b

We report three newly discovered exoplanets from the SuperWASP survey. WASP-127b is a heavily inflated super-Neptune of mass 0.18MJ and radius 1.35RJ. This is one of the least massive planets discovered by the WASP project. It orbits a bright host star (Vmag = 10.16) of spectral type G5 with a period of 4.17 days. WASP-127b is a low density planet which has an extended atmosphere with a scale h...